P1-13 Indicative microorganisms associated with the progression of esophageal squamous cell carcinoma (ESCC) in China

The relationship between microbiota and esophageal squamous cell carcinoma (ESCC) progression is still unclear, especially microbiota. We collected biopsy swab samples from 236 participants in health diseases Linzhou. With the average relative abundance (ARA%) of as baseline, this study compared baseline with other groups by Wilcoxon test respectively, ARA% among five was analyzed Kruskal-Wallis test. A number 109 microorganisms were characterized into genus level both specimens on basis 16SrRNA sequencing data. There 12 indicative, same, consistent identified two specimens, including Neisseria, Haemophilus, Aggregatibacter, Fusobacterium, Bergeyella, Selenomonas, Oribacterium, Alysiella, Filifactor, Novosphingobium, Streptococcus f__Lachnospiraceae. first eight increasing normal to ESCC, while others decreasing. Sphingomonas unique one statistical difference four respectively but only biopsy. flora LGIN above groups, Aeromonas, Fretibacterium, Filifactor Solobacterium, which all decreasing tendency. are complicated dynamic changing indicative provides scientific evidence for early detection diagnosis ESCC via easy-collected oral sample. However, more multi-center, large sample size, prospective studies needed future.